Mark，芝加哥大学 E. J. Sheffield集团最近取得了新的成就。通过不懈的努力，他们的最新研究揭示了突触可塑性规则驱动海马体的特征转移。该研究成果于2025年3月20日在国际顶级学术期刊《自然神经科学》上发表。

研究小组认为海马体位置场(PF)它是记忆形成和熟悉过程中持续可塑性的指标。研究小组的研究人员通过在脉冲位置细胞的计算模型中实施不同的可塑性规则，并将其与在熟悉和新环境中导航时实验测量的突触可塑性进行比较，发现行为时间尺度的突触可塑性(BTSP)，而非Hebbian脉冲时间依赖于可塑性(STDP)，脉冲位移动力学是最好的解释。引发btsp的事件很少，但在新的体验中更频繁。在探索过程中，它们的概率是动态的——它们在PF攻击后衰减，但它们继续促进具有代表性的种群漂移。此外，他们的结果表明，BTSP发生在CA3中，但频率较低，与CA1不同。一般来说，他们的研究为理解突触可塑性如何在学习过程中不断塑造神经元特征提供了一个新的框架。

研究人员表示，突触的可塑性被广泛认为支持大脑中的记忆存储，但决定体内有效突触变化的规则尚不清楚。

附：英文原文

Title: Synaptic plasticity rules driving representational shifting in the hippocampus

Author: Madar, Antoine D., Jiang, Anqi, Dong, Can, Sheffield, Mark E. J.

Issue&Volume: 2025-03-20

Abstract: Synaptic plasticity is widely thought to support memory storage in the brain, but the rules determining impactful synaptic changes in vivo are not known. We considered the trial-by-trial shifting dynamics of hippocampal place fields (PF) as an indicator of ongoing plasticity during memory formation and familiarization. By implementing different plasticity rules in computational models of spiking place cells and comparing them to experimentally measured PFs from mice navigating familiar and new environments, we found that behavioral timescale synaptic plasticity (BTSP), rather than Hebbian spike-timing-dependent plasticity (STDP), best explains PF shifting dynamics. BTSP-triggering events are rare, but more frequent during new experiences. During exploration, their probability is dynamic—it decays after PF onset, but continually drives a population-level representational drift. Additionally, our results show that BTSP occurs in CA3 but is less frequent and phenomenologically different than in CA1. Overall, our study provides a new framework to understand how synaptic plasticity continuously shapes neuronal representations during learning.

DOI: 10.1038/s41593-025-01894-6

Source: https://www.nature.com/articles/s41593-025-01894-6